PSMA-homing dsRNA chimeric protein vector kills prostate cancer cells and activates anti-tumor bystander responses
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چکیده
منابع مشابه
PSMA-homing dsRNA chimeric protein vector kills prostate cancer cells and activates anti-tumor bystander responses
The treatment of metastatic androgen-resistant prostate cancer remains a challenge. We describe a protein vector that selectively delivers synthetic dsRNA, polyinosinic/polycytidylic acid (polyIC), to prostate tumors by targeting prostate specific membrane antigen (PSMA), which is overexpressed on the surface of prostate cancer cells.The chimeric protein is built from the double stranded RNA (d...
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Prostate cancer is the second most common cancer in men worldwide, and the eighth leading cause of cancerrelated death. Globally, there are approximately 1,100,000 new cases and 300,000 mortalities every year, comprising nearly 4 percent of all cancer deaths. It is estimated that 1 in every 7 men will be diagnosed with the disease during his lifetime[1]. The most dangerous stage of prostate can...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2017
ISSN: 1949-2553
DOI: 10.18632/oncotarget.15733